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Glutathione is classified as Generally Recognized as Safe (GRAS) by the FDA when used as a dietary supplement, but this doesnt extend to IV administration for aesthetic treatments

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CDs were dissolved in solution A (final concentration 5 g/mL) and TMB was dissolved in solution B (final concentrations 100, 200, 300, 400, and 500 M, respectively)

and 4 for extremely severe signs (extremely severe facial swelling, copious nasal discharge, tearing, fully closed eyes)